Overview
Big data and machine learning are influencing almost every aspect of modern life, including entertainment, commerce, and healthcare. Netflix knows which films and series people like to watch, Amazon knows which items people like to buy when and where, and Google knows which symptoms and conditions people look up.
All of this information can be used to create highly detailed personal profiles, which can be useful not only for behavioral understanding and targeting, but also for predicting healthcare trends. There is great hope that the application of artificial intelligence (AI) will result in significant improvements in all areas of healthcare, from diagnostics to treatment. It is widely assumed that AI tools will facilitate and enhance human work rather than replace it.
Technological Advancements
There have been a great number of technological advances within the field of AI and data science in the past decade. Although research in AI for various applications has been ongoing for several decades, the current wave of AI hype is different from the previous ones. A perfect combination of increased computer processing speed, larger data collection data libraries, and a large AI talent pool has enabled rapid development of AI tools and technology, also within healthcare [5]. This is set to make a paradigm shift in the level of AI technology and its adoption and impact on society.
In particular, the development of deep learning (DL) has had an impact on the way we look at AI tools today and is the reason for much of the recent excitement surrounding AI applications. DL allows finding correlations that were too complex to render using previous machine learning algorithms. This is largely based on artificial neural networks and compared with earlier neural networks, which only had 3–5 layers of connections, DL networks have more than 10 layers. This corresponds to simulation of artificial neurons in the order of millions.
There are numerous companies that are frontrunners in this area, including IBM Watson and Google’s Deep Mind. These companies have shown that their AI can beat humans in selected tasks and activities including chess, Go, and other games. Both IBM Watson and Google’s Deep Mind are currently being used for many healthcare-related applications. IBM Watson is being used to investigate for diabetes management, advanced cancer care and modeling, and drug discovery, but has yet to show clinical value to the patients. Deep Mind is also being looked at for applications including mobile medical assistant, diagnostics based on medical imaging, and prediction of patient deterioration [6], [7].
Precision Medicine
It is believed that within the next decade a large part of the global population will be offered full genome sequencing either at birth or in adult life. Such genome sequencing is estimated to take up 100–150 GB of data and will allow a great tool for precision medicine. Interfacing the genomic and phenotype information is still ongoing. The current clinical system would need a redesign to be able to use such genomics data and the benefits hereof [13].
Deep Genomics, a Healthtech company, is looking at identifying patterns in the vast genetic dataset as well as EMRs, in order to link the two with regard to disease markers. This company uses these correlations to identify therapeutics targets, either existing therapeutic targets or new therapeutic candidates with the purpose of developing individualized genetic medicines. They use AI in every step of their drug discovery and development process including target discovery, lead optimization, toxicity assessment, and innovative trial design.
Many inherited diseases result in symptoms without a specific diagnosis and while interpreting whole genome data is still challenging due to the many genetic profiles. Precision medicine can allow methods to improve identification of genetic mutations based on full genome sequencing and the use of AI.
Solution
We believe that AI has an important role to play in the healthcare offerings of the future. In the form of machine learning, it is the primary capability behind the development of precision medicine, widely agreed to be a sorely needed advance in care. Although early efforts at providing diagnosis and treatment recommendations have proven challenging, we expect that AI will ultimately master that domain as well. Given the rapid advances in AI for imaging analysis, it seems likely that most radiology and pathology images will be examined at some point by a machine. Speech and text recognition are already employed for tasks like patient communication and capture of clinical notes, and their usage will increase.
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